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Macronutrients and aging

Macronutrients and aging

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What you need to know about macronutrients

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A Macronutrients and aging target for Unbeatable Macronutrients and aging delaying aging agnig cellular senescence, a Aand of stable growth arrest that is accompanied ans various structural and functional Macronutrisnts including the activation of a pro-inflammatory secretome.

Here, we summarize the current knowledge on the molecular and cellular events associated with carbohydrate, lipid and protein metabolism, and define how macronutrients can regulate induction or prevention of cellular senescence.

We discuss how various dietary interventions can achieve prevention of disease and extension of healthy longevity by partially modulating senescence-associated phenotypes. We also emphasize the importance of developing personalized nutritional interventions that take into account the current health and age status of the individual.

Keywords: Aging; Macronutrients; Metabolism; Senescence. Copyright © The Authors. Published by Elsevier B. All rights reserved. Abstract Evidence supports the notion that metabolic pathways are major regulators of organismal aging, and that metabolic perturbations can extend health- and lifespan. Publication types Review.

: Macronutrients and aging

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Frontiers | Editorial: Nutrition and metabolic aging Afing associations between macronutrient intakes and Agjng were investigated. Midlife crisis in women, once Macronutrients and aging a Macronutrienhs, is Macronutrients and aging well-documented Macronutruents for many. The ability to synthesize V itamin D from sunlight Macronutgients activated calcitriol decreases Macronktrients age, so older adults need Recover from muscle soreness exposure to sunlight to produce the required amount. Finally, two interesting studies in this Research Topic demonstrate the harmful effects of undernutrition in obesity, and the importance of magnesium and calcium intake to prevent hearing loss in humans. Aging can also affect your sense of smell and taste, making foods seem less appealing examine the impact of dairy products on non-alcoholic fatty liver disease NAFLD. Duan H, Pan J, Guo M et al Dietary strategies with anti-aging potential: dietary patterns and supplements.
Macronutrients and Their Roles in Aging

Since carbs provide the body with energy, a deficiency can make you feel tired and sluggish. You may also experience muscle loss, lack of stamina, poor immunity. Too much of anything is never good. Eating too many carbohydrate-dense foods can put your body at risk of hypoglycemia, insulin resistance, and type 2 diabetes.

Fat plays an essential role in inflammation regulation. Dietary fats provide energy, help manufacture and balance hormones, form cell membranes, and transport vitamins.

We can get HEALTHY fats from nuts, seeds, coconut, avocado, olives, and egg yolks. There are two types of fiber, soluble and insoluble. Soluble fiber absorbs liquid and functions to bind things like excess cholesterol and lubricate bowls. It lowers the glycemic load of food to help regulate blood sugar.

Bananas, carrots, sweet potatoes, almonds, and flax are all sources of soluble fibers. Insoluble fiber does not dissolve in liquids.

It has a more rigid texture and adds bulk to food to help us feel satisfied. It also adds dimension to stool as it moves through the digestive tract to aid bowel movements. Whole grains, nuts, seeds, celery, and kale are all sources of insoluble fiber.

The best way to increase fiber intake is by eating plants with plenty of beneficial vitamins and minerals. Eat a mix of soluble and insoluble fibers with every meal. Shoot for g fiber per day. Overall, a healthy diet made mostly of whole, minimally processed foods will provide us with the best health benefits.

StrongerLife is a senior group fitness program for adults 55 and over in Lexington, KY. If you need help with nutrition or have any questions about our program call us at Macronutrients for the Older Adult.

Mar 11 Written By Trisha Krystman. Macronutrients What is a Macronutrient? Engelfriet PM, Jansen EHJM, Picavet HSJ, Dollé MET Biochemical markers of aging for longitudinal studies in humans. Epidemiol Rev — Fanson BG, Taylor PW Protein:carbohydrate ratios explain life span patterns found in Queensland fruit fly on diets varying in yeast:sugar ratios.

Age Dordr — Farhadnejad H, Asghari G, Teymoori F et al Low-carbohydrate diet and cardiovascular diseases in Iranian population: Tehran Lipid and Glucose Study.

Nutr Metab Cardiovasc Dis — Foscolou A, Magriplis E, Tyrovolas S et al The association of protein and carbohydrate intake with successful aging: a combined analysis of two epidemiological studies.

Eur J Nutr — Foscolou A, Critselis E, Tyrovolas S et al The association of animal and plant protein with successful ageing: a combined analysis of MEDIS and ATTICA epidemiological studies. Public Health Nutr — Gao Y, Zhang W, Zeng L-Q et al Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy.

Redox Biol Gavrilova NS, Gavrilov LA Comments on dietary restriction, Okinawa diet and longevity. Gerontology — Alzheimers Dement — Giezenaar C, Oberoi A, Jones KL et al Effects of age on blood pressure and heart rate responses to whey protein in younger and older men.

J Am Geriatr Soc — Glassock RJ, Rule AD Aging and the kidneys: anatomy, physiology and consequences for defining chronic kidney disease. Nephron — Gopinath B, Harris DC, Flood VM et al Carbohydrate nutrition is associated with the 5-year incidence of chronic kidney disease.

J Nutr — Gopinath B, Flood VM, Burlutksy G et al Association between carbohydrate nutrition and prevalence of depressive symptoms in older adults. Br J Nutr — Hashemi R, Motlagh AD, Heshmat R et al Diet and its relationship to sarcopenia in community dwelling Iranian elderly: a cross sectional study.

Nutrition — van Heemst D Insulin, IGF-1 and longevity. Aging Dis — PubMed PubMed Central Google Scholar. Jaul E, Barron J Age-related diseases and clinical and public health implications for the 85 years old and over population.

Front Public Health Jung C-H, Choi KM Impact of high-carbohydrate diet on metabolic parameters in patients with type 2 diabetes. Kalscheuer H, Serfling G, Schmid S, Lehnert H [Diabetic emergencies: Hypoglycemia, ketoacidotic and hyperglycemic hyperosmolar nonketotic coma].

Internist Berl — Kehoe L, Walton J, Flynn A Nutritional challenges for older adults in Europe: current status and future directions. Proc Nutr Soc — Kitada M, Ogura Y, Monno I, Koya D The impact of dietary protein intake on longevity and metabolic health. EBioMedicine — Kökten T, Hansmannel F, Ndiaye NC et al Calorie restriction as a new treatment of inflammatory diseases.

Adv Nutr — Krebs-Smith SM, Pannucci TE, Subar AF et al Update of the Healthy Eating Index: HEI J Acad Nutr Diet — Kurozumi A, Okada Y, Mori H et al Detrimental effects of high-fat diet loading on vascular endothelial function and therapeutic efficacy of ezetimibe and statins in patients with type 2 diabetes.

Endocr J — Wiad Lek — Le Couteur DG, Solon-Biet SM, Cogger VC et al Branched chain amino acids, aging and age-related health. Ageing Res Rev Lee S-J, Murphy CT, Kenyon C Glucose shortens the life span of C.

Cell Metab — Lee D, Son HG, Jung Y, Lee S-JV The role of dietary carbohydrates in organismal aging. Cell Mol Life Sci — Maturitas — Levine ME, Suarez JA, Brandhorst S et al Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

Liput KP, Lepczyński A, Ogłuszka M et al Effects of dietary n-3 and n-6 polyunsaturated fatty acids in inflammation and cancerogenesis. Int J Mol Sci Maeso-Díaz R, Gracia-Sancho J Aging and chronic liver disease. Semin Liver Dis — McCarty MF A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process.

Med Hypotheses — Mirmiran P, Yuzbashian E, Asghari G et al Dietary fibre intake in relation to the risk of incident chronic kidney disease. Montalvany-Antonucci CC, Zicker MC, Macari S et al High-refined carbohydrate diet promotes detrimental effects on alveolar bone and femur microarchitecture.

Arch Oral Biol — Morris BJ A forkhead in the road to longevity: the molecular basis of lifespan becomes clearer. J Hypertens — Naseeb MA, Volpe SL Protein and exercise in the prevention of sarcopenia and aging.

Nutr Res — Ni Lochlainn M, Bowyer RCE, Steves CJ Dietary protein and muscle in aging people: the potential role of the gut microbiome. Norman K, Klaus S Veganism, aging and longevity: new insight into old concepts. Curr Opin Clin Nutr Metab Care — Curr Opin Endocrinol Diabetes Obes — Pan H, Finkel T Key proteins and pathways that regulate lifespan.

J Biol Chem — Park Y, Subar AF, Hollenbeck A, Schatzkin A Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med — Peyron MA, Woda A, Bourdiol P, Hennequin M Age-related changes in mastication.

J Oral Rehabil — Sadighi Akha AA Aging and the immune system: an overview. J Immunol Methods — Santos AL, Sinha S Obesity and aging: molecular mechanisms and therapeutic approaches. Sartorius K, Sartorius B, Madiba TE, Stefan C Does high-carbohydrate intake lead to increased risk of obesity?

A systematic review and meta-analysis. BMJ Open 8:e Scott S, Kempf P, Bally L, Stettler C Carbohydrate intake in the context of exercise in people with type 1 diabetes. Seidelmann SB, Claggett B, Cheng S et al Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis.

Lancet Public Health 3:e—e Sheedfar F, Di Biase S, Koonen D, Vinciguerra M Liver diseases and aging: friends or foes?

Aging Cell — Simpson SJ, Le Couteur DG, James DE et al a The Geometric Framework for Nutrition as a tool in precision medicine. Nutr Healthy Aging — Simpson SJ, Le Couteur DG, Raubenheimer D et al b Dietary protein, aging and nutritional geometry. Ageing Res Rev — Soenen S, Rayner CK, Jones KL, Horowitz M The ageing gastrointestinal tract.

Author contributions

A common target for metabolic interventions delaying aging is cellular senescence, a state of stable growth arrest that is accompanied by various structural and functional changes including the activation of a pro-inflammatory secretome.

Here, we summarize the current knowledge on the molecular and cellular events associated with carbohydrate, lipid and protein metabolism, and define how macronutrients can regulate induction or prevention of cellular senescence.

We discuss how various dietary interventions can achieve prevention of disease and extension of healthy longevity by partially modulating senescence-associated phenotypes. We also emphasize the importance of developing personalized nutritional interventions that take into account the current health and age status of the individual.

Keywords: Aging; Macronutrients; Metabolism; Senescence. Copyright © The Authors. In recent years, several nutritional interventions have been identified that profoundly impact the aging process.

These interventions can increase healthspan the component of life that is generally healthy and devoid of chronic disorders and lifespan. In this Research Topic, original research studies eloquently demonstrate how nutrition affects healthspan in pre-clinical models and humans Figure 1.

Figure 1. Various nutritional interventions and nutrient statuses that influence metabolic health with aging. CR extends healthspan and lifespan in many pre-clinical models, and in this Research Topic, one study builds upon these findings.

Teofilović et al. Interestingly, the authors find that these improvements were associated with increased liver inflammation, which may have been partly due to the older age of the rats.

The results of this study underscore the need to carefully consider several factors when investigating the effects of CR in health and disease, including the age of an individual, nutritional status, and treatment duration 4. In addition to CR, the role of dietary macronutrients protein, carbohydrates, and fats in modulating health has been the focus of much research 5.

In this Research Topic, several studies explore the impact of macronutrient consumption in health and disease. Here, Sumi et al. investigate the effects of a low carbohydrate ketogenic diet or a high-fat, high carbohydrate diet in mice with reduced citrate synthase activity [an enzyme most often responsible for catalyzing the first reaction of the citric acid TCA cycle].

Interestingly, the findings of this study show that in the presence of a low-carbohydrate diet, these mice exhibit tissue-specific metabolic adaptations including decreased glycogen levels, suppression of growth pathways, and muscle atrophy. These results provide an overview of how different organs use fuel under varying energy conditions and provide insight into how metabolic disorders are related to impaired TCA cycle metabolism.

Like dietary fats and carbohydrates, dietary protein also has a profound impact on aging 6. Here, Zheng W. et al. provide insight into optimal protein consumption in older age by examining the influence of ad-libitum lower protein or higher protein diets on metabolic health in rats, and whether increasing dietary protein intake in older age improves health.

The authors performed comprehensive assessments of behavior, the circulating metabolome, inflammation, and health, and found that shifting from lower protein consumption in younger age to higher protein consumption in older age improves select health outcomes.

These results provide insight into how protein requirements change with advancing age, and the importance of protein quantity in health and disease. Dietary fat also has an important impact on aging and age-related disease.

Traditionally, chronic consumption of a high-fat Western-style diet augments age-associated disease and decreases healthspan, but many of these studies have been performed in genetically homogenous murine models.

In this Research Topic, Zheng X. study the effects of a chronic high-fat Western-style diet on metabolic and arterial function in outbred, genetically diverse mice—a model that has greater potential for translation to humans relative to inbred strains.

The authors found that consumption of a Western-style diet increased aortic stiffness and systolic blood pressure and decreased vascular endothelial function, which are all independent predictors of cardiovascular-related morbidity and mortality 7.

Importantly, these effects varied between male and female mice, emphasizing the importance of considering sex as a biological variable when assessing differences in responses to certain dietary interventions. Li et al. build upon these findings in mice by performing a meta-analysis to study the links between saturated fatty acid metabolites and cardiovascular disease in humans.

The results, which include 49 prospective studies, show that a higher abundance of circulating saturated fatty acids is associated with an increased risk of cardiometabolic disease and stroke. Similarly, Keshavarz et al. examine the impact of dairy products on non-alcoholic fatty liver disease NAFLD.

The authors use measures of liver enzymes, lipid profiles, and glycemic indexes to broadly characterize liver health and find that higher milk consumption is associated with reduced incidence of NAFLD. This Research Topic also contains studies that provide insight into how certain dietary patterns, macronutrients, or micronutrients affect health in humans.

One strong measure of healthspan in humans is glucose tolerance, and several metabolic conditions coincide with higher than average blood glucose levels 8. In this Research Topic, Ji et al. These results highlight the role of blood glucose in aging and emphasize the need to maintain blood glucose within a certain range to maintain healthy aging.

Finally, two interesting studies in this Research Topic demonstrate the harmful effects of undernutrition in obesity, and the importance of magnesium and calcium intake to prevent hearing loss in humans. In the first study, Sulmont-Rossé et al. These results highlight the fact that more work needs to be done to comprehensively understand the role of undernourishment in affecting overweight and obesity.

In the second study, Wei examined the impact of dietary magnesium and calcium intake on hearing loss in older adults and found that increased consumption of these minerals is associated with improved hearing function.

These data highlight the complexity of the role of nutrition in aging and the need to consider micronutrient quantity and quality when studying metabolic health outcomes.

As the world's population ages, the burden of age-related disease magnifies. In this Research Topic, important original research studies show that healthspan can be improved with specific nutritional interventions including a reduction in caloric or saturated fat intake, optimizing dietary macronutrient consumption, increasing intake of specific minerals, and ensuring nutritional requirements are met.

Together, these excellent papers provide a major step forward into our understanding of how nutrition impacts health and paves a path for future research on the role of nutrition in metabolic aging. All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.

The authors acknowledge www. com for graphical support. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Eating healthy ahing Macronutrients and aging important as you age. Luckily, there are things Macronutrients and aging MMacronutrients do to help prevent Macronutrient and other age-related changes. For example, Macronitrients nutrient-rich foods and taking the appropriate supplements can help keep you healthy as you age. This article explains how your nutritional needs change as you age, including how to address them. Aging is linked to a variety of changes in the body, including muscle loss, thinner skin and less stomach acid.

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